Margaret Mitchell/Synopsis

The Guild Arc
Like many other members of the Guild, Mitchell arrives together with them as "the package". Once wiping out both the Port Mafia and the Armed Detective Agency, Nathaniel Hawthorne asks about the whereabouts of Edgar Allan Poe and Louisa May Alcott, to which Mitchell answers that they stayed behind.

She later reappears when she is seen giving directions to the workers to load the cargo. Being the only one working, she gives a scornful gaze to Hawthorne, who is calmly reading his Bible. Upset about this, she proceeds to make use of her ability to destroy the book, getting his attention; then she remembers him about their mission to protect this cruiser that serves as their base.

The pair's discussion eventually evolves into a little quarrel, before being interrupted by a worker who brought a found letter to them. There she reads about Ōgai Mori's plan to eliminate her together with his partner and the cruiser, taking the said threat as some kind of joke and underestimating the organization, only to be scolded by Hawthorne. Once again, they are interrupted by the discovery of a suspicious man.

Mitchell calls him a thug and then asks her partner to let her turn him into a mummy, but it is stopped by him. After Hawthorne supposedly gets rid of Kajii, she is about to resume her activities, but is shocked when she found that the explosion had no effect on him, and even more so when hundreds of lemon-shaped bombs fall from the sky. Being forced to abandon the ship, the woman jumps together with Hawthorne in order to survive the attack and then expresses her shock. Seeing that it wasn't a prank, they decide together to retreat to an evacuation route.

Mitchell then discovers the Guild's senior secretary and rushes to him, but then discovers that it was nothing but a trap (of the many others) set up by Kajii. After being protected by Hawthorne, she stares in surprise the reflected explosion and then retreats again to find a group of survivors. Just when they are about to think of a strategy and get ready for combat, she is impaled with the others by Ryunosuke Akutagawa's ability, Rashōmon.

It is later shown that she survived the initial attack and starts yelling at the assassin, claiming to be her duty to salvage the reputation of her family and that he has known no defeat. Due to this, she is later thoroughly impaled again, this time seeming dead. Once again, however, she is able to withstand death and rushes to shield Hawthorne from Akutagawa's final attack, sacrificing herself.

After the battle with Akutagawa, she survives together with Hawthorne but in an entirely worse condition, ending up in a coma.

Hunting Dogs Arc
With the Guild and her family having gone bankrupt, Mitchell's condition worsens. Nevertheless, she is apparently being looked after by Fitzgerald and his medical team somewhere in his base until Atsushi Nakajima's intervention in seeking out his Eyes of God. With Fitzgerald wishing to have the Agency doctor revive Mitchell, he plans on having her defeat a brainwashed Hawthorne, which Fitzgerald claims is the only way to prevent any more interference from the reverend. Though Atsushi initially declines and almost backs out of the deal, seeing Mitchell's declining condition compels Atsushi to agree with his terms. Mitchell is then loaded to a truck and brought on the way to Yosano.

She was then healed by Yosano after the latter encounters Atsushi and Kyōka.